منابع مشابه
Taking risks with translational research.
The recent bankruptcy filing by deCODE, a company with an exceptional pedigree in associating genetic variance with disease onset, highlights the commercial risks of translational research. Indeed, deCODE's approach was similar to that adapted by academic researchers who seek to connect genetics and disease. We argue here that neither a purely corporate nor purely academic model is entirely app...
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It is now readily possible to determine, often in exquisite detail, the ways in which a single cell or a single individual differs from another. Although we are rapidly figuring out how these cellular features are altered in disease states, pulling medical advances from this haystack of facts remains a challenge. Yet, the view from Cell on prospects for medical advancement in this era of integr...
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At SMARTRISK, we want you to take risks. Don't forget your helmet, or your parachute. It's that simple. — SMARTRISK home page 1 I t is widely accepted that new public health initiatives should be scrutinized, just as we scrutinize the evidence on new drugs. Ideally, such programs should be evaluated before or soon after they are introduced, especially if they take a novel and untested approach ...
متن کاملTaking a translational turn
This month's installment of Generally Physiological takes a translational turn, discussing functional analyses of two proteins whose mutation is associated with disease (heart failure and cystic fibrosis, respectively) and the mechanism underlying the painful response to cold found in ciguatera. A tunable brake on cardiac contractility Cardiac contraction, like that of skeletal muscle, depends ...
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I was working recently with a group of Danish doctors on a course where they had a chance to talk about some of their most difficult patients: complex cases, challenging ones, people who had worn them down over the years by consulting very often but never getting any better. One theme came up again and again in their stories. It was the theme of risk. The doctors on the course didn’t mean the k...
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ژورنال
عنوان ژورنال: Science Translational Medicine
سال: 2010
ISSN: 1946-6234,1946-6242
DOI: 10.1126/scitranslmed.3000667